李墅 导师简介
发布日期:2024-03-04   作者:研办  浏览数:918



一、基本信息

  李墅,理学(生物化学与分子生物学)博士,石河子大学药学院药学系副教授。主要致力于基于多肽的抗耐药菌新药发现、设计合成以及作用机制的研究,在Chemical Communications, ACS Infectious Diseases, Bioconjugate  Chemistry等学术期刊发表论文8篇。

二、讲授课程

 本科生课程:分析化学、工业药物分析

 研究生课程:生物技术制药

三、代表性成果(从近到远……)

1.  代表论文

  [1] Li S, Wang Z, Song S, Tang Y, Zhou J, Liu X, Zhang X, Chang M, Wang K, Peng Y, Membrane-Active All-Hydrocarbon-Stapled α-Helical Amphiphilic Tat Peptides: Broad-Spectrum Antibacterial Activity and Low Incidence of Drug Resistance. ACS Infectious Diseases, 2024.04.12, Accept, DOI:10.1021/acsinfecdi s.4c00173.

  [2] Li S, Song S, Liu X, Zhang X, Liang X, Chang X, Zhou D, Han J, Nie Y, Guo C, Yao X, Chang M, Peng Y, Development of a Decafluorobiphenyl Cyclized Peptide Targeting the NEMO–IKKα/β Interaction that Enhances Cell Penetration and Attenuates Lipopolysaccharide-Induced Acute Lung Injury, Bioconjugate Chemistry, 2024.4.16, Accept, DOI: 10.1021/acs.bioconjchem.4c00122.

  [3] Li S, Guo C, Zhang X, Liu X, Mu J, Liu C, et al. Self-assembling modified neuropeptide S enhances nose-to-brain penetration and exerts a prolonged anxiolytic-like effect. Biomater. Sci, 2021. DOI: 10.1039/D1BM00380A.

  [4] Li S, Zhang X, Guo C, Peng Y, Liu X, Wang B, et al. Hydrocarbon staple constructing highly efficient α-helix cell-penetrating peptides for intracellular cargo delivery. Chem. Commun, 2020; 56(100):15655-15658.

  [5] Jiang J, Wang Z, Liang, X. Y.; Nie, Y. Y.; Chang, X.; Xue, H. X.; Li, S.; Min, C. Intranasal MMI-0100 Attenuates A beta (1-42)- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway. Front. Immunol, 2019, 10, 16.

  [6] Jiang, J. H.; Peng, Y. L.; Liang, X. Y.; Li, S.; Chang, X.; Li, L. F.; Chang, M. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABA(A) Receptor Signaling Pathway. Front. Pharmacol. 2018, 9, 12.

  [7] Jiang, J. H.; Jin, W. D.; Peng, Y. L.; Liang, X. Y.; Li, S.; Wei, L. J.; Lei, Z. P.; Li, L. F.; Chang, M. The role of Cortistatin-14 in the gastrointestinal motility in mice. Pharmacol. Rep. 2018, 70, 355-363.

  [8] Jiang, J. H.; Jin, W. D.; Peng, Y. L.; He, Z.; Wei, L. J.; Li, S.; Wang, X. L.; Chang, M.; Wang, R. In vivo and vitro characterization of the effects of kisspeptin-13, endogenous ligands for GPR54, on mouse gastrointestinal motility, Eur. J. Pharmacol. 2017, 794, 216-223.

2.  发明专利

[1] 彭雅丽,李墅,常民,宋世博;“烯烃装订的两亲性肽及其制备方法和应用”,申请号:2023102895231 申请日:2023-01-28.

[2] 彭雅丽,李墅,张兴姣,高飞云,常民;“十氟联苯环化修饰的 NBD 多肽类似物及其制备方法和应用”,申请号:202110619708 申请日:2021-08-06.已授权

[3] 常民, 穆静, 彭雅丽, 李墅, 王沛, 刘春霞, 姜锦红; “脂肪酸修饰神经肽 S 类似物及其合成与应用”, 申请号:201810408033.8 申请日:2018-05-02. 已授权.

[4] 常民, 彭雅丽, 李墅, 薛宏祥; “一种高效的前列腺特异性膜抗原配体 PSMA-617 的固相制备方法”, 申请号:201810984865.4 申请日:2018-08-28.已授权.

四、联系方式

1.  E-maillishu14@lzu.edu.cn

2.  通讯地址:新疆维吾尔自治区石河子市,北259号,石河子大学医学校区,药学院

3. 邮编:832002