一、 基本信息

阿瓦古丽·达吾提，北京协和医学院药理学医学博士，新疆维吾尔自治区“天池英才”青年博士人才。主要致力于新疆地产民族药活性成分的发现、作用靶点和药理机制研究。目前主持天池英才项目1项。在Biomedicine & pharmacotherapy， International journal of molecular science，Aging等学科一流或学科重要杂志上发表SCI论文6篇。参编著名出版社Springer出版的英文论著《Aquaporins》。

二、主持科学研究项目

1.自治区“天池英才”青年博士人才项目《维药益心巴迪然吉布亚颗粒对HFpEF的治疗作用、关键成分发现与靶点确认》。 

三、讲授课程

1. 本科生课程：《药理学》《药理学实验》《药物毒理学》 

四、代表性成果

[1]Awaguli Dawuti, Shuchan Sun , Ranran Wang, Difei Gong, Ruiqi Liu , Dewen Konga，Tianyi Yuan, Jian Zhou, Yang Lu , Shoubao Wang , Guanhua Du, Lianhua Fang. Salvianolic acid A alleviates heart failure with preserved ejection fraction via regulating TLR/MyD88/TRAF/NF-κB and p38MAPK/CREB signaling pathways. Biomedicine & pharmacotherapy, 2023, 168: 115837.（IF= 7.5）

[2]Awaguli Dawuti, Shuchan Sun, Ranran Wang, Difei Gong, Tianyi Yuan, Li Zhang, Shiying Yang, Yang Lu, Shoubao Wang, Lianhua Fang, Guanhua Du. Systems Pharmacology-Based Strategy to Investigate Pharmacological Mechanisms of Total Flavonoids in Dracocephalum Moldavica on Chronic Heart Failure. Int J Mol Sci.2022 Jul;23(15):8409.（IF= 5.6）

[3]Awaguli Dawuti, Lisha Ma, Xueyan An, Jiawei Guan, Changdong Zhou, Linyun He, Yue Xu, Bo Han, Abudumijiti Abulizi. Exploring the effect and mechanism of Aloin A against cancer cachexia-induced muscle atrophy via network pharmacology, molecular docking, molecular dynamics and experimental validation. Aging. 2023 Dec 29;15(24):15557-15577. (IF=5.2)

[4]Shuchan Sun, Awaguli Dawuti, Difei Gong, Ranran Wang, Tianyi Yuan, Shoubao Wang, Cheng Xing, Yang Lu, Guanhua Du, Lianghua Fang. Puerarin-V improve mitochondrial respiration and cardiac function in a rat model of diabetic cardiomyopathy via inhibiting pyroptosis pathway through P2X7 receptors. Int J Mol Sci. 2022 Oct 27; 23(21):13015.  (IF= 5.6)

[5]Difei Gong, Shuchan Sun, Ranran Wang, Awaguli Dawuti, Dewen Kong, Ruiqi Liu, Lida Du, Shoubao Wang, Yang Lu, Tianyi Yuan, Guanhua Du, Lianhua Fang. Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy. Biomedicine & pharmacotherapy. 2023 Apr: 160:114382. (IF=7.5)

[6]Difei Gong, Tianyi Yuan, Ranran Wang, Shuchan Sun, Awaguli Dawuti, Shoubao Wang, Guanhua Du, Lianhua Fang. Network pharmacology approach and experimental verification of Dan-Shen Decoction in the treatment of ischemic heart disease. Pharm Biol. 2023 Dec;61(1):69-79. (IF=3.55)

[7]阿瓦古丽·达吾提，方莲花，杜冠华. 丹酚酸对缺血性心脏病的作用及作用机制研究进展[J].药学学报, 2021, 56(02):368-373. (北大核心)

[8]阿瓦古丽·达吾提，任利文，王冉冉，方莲花，杜冠华. 治疗心力衰竭中药有效成分网络药理学研究[J]. 中药药理与临床, 2020, 36(5):131-136. (北大核心)

[9]阿瓦古丽·达吾提, 刘丹，阿迪拉·迪力夏提，阿布来提·阿布力孜，阿地力江·萨吾提，艾再提·克日木，阿迪力·阿不都热合曼，邬利娅·伊明. 性别及雌激素水平对肾血管性高血压大鼠血管组织ACE1-AngⅡ-ATR轴的影响[J].中国药理学通报, 2019, 35(06):859-863. (北大核心)

五、联系方式

1.  E-mail：awaguli@shzu.edu.cn

2.  通讯地址：新疆维吾尔自治区石河子市，北2路59号，石河子大学医学校区，药学院

3. 邮编：832002