一、基本信息
张珂,校级“3152”青年骨干教师,中国民族医药学会科研分会青年委员,中国医药信息研究会食疗分会理事。长期从事中药和民族药物质基础及生物活性的研究工作。主讲《高等药理学》与《高等药理学技术》等研究生专业课程。担任普通高等教育“十四五”规划教材《天然药物化学》第一副主编。近5年主持国家重大专项子课题、国家自然科学基金、兵团科技专项基金各1项,校级项目2项,横向课题1项。以第一或通讯作者在Biomedicine & Pharmacotherapy, Fitoterapia等刊物上发表国际高水平论文10余篇,授权专利1项,获黑龙江省科学技术进步奖二等奖1项(排名第5),自治区自然科学优秀学术论文奖二等奖1项。
二、主持科学研究项目
1. 石河子大学2020年度自主资助支持校级科研立项项目《维药百藓夏塔热片治疗银屑病的作用机制研究》(ZZZC202086A)。
2. 国家科技重大专项重大新药创制《中药民族药组分资源库建设》(2018ZX09735-005)。
3. 国家自然科学基金地区项目《蝉蜕中乙酰多巴胺二聚体改善紫癜性肾炎活性及其作用机制研究》(81860725)。
4. 横向研发项目《蔷薇红景天总苷制备技术》。
3. 横向研发项目《脾多肽对卵巢癌患者代谢组学影响研究》。
5. 国家自然科学基金地区项目《圆根大戟和甘遂中保护多巴胺所致SH-SY5Y细胞损伤帕金森模型作用和机制研究》(81260628)。
6. 横向研发项目《脾多肽对卵巢癌患者代谢组学影响研究》。
7. 2017年高层次人才科研启动金项目《蒙药复方冬青叶颗粒剂治疗过敏性哮喘的新药临床前研究开发》。
三、主持教学研究项目
1. 石河子大学2019教育教学改革项目《中药化学实验混合式教学改革初探》(JGY-2019-35)2018.09-2020.09,1万元.
四、讲授课程
1. 硕士研究生:高等药理学,高等药理学技术,药学专论与论文写作等
2. 本科生课程:药理学实验
五、代表性成果
1. 代表论文
[1] Ma Qingdong, Ke Zhang*, Guoyu Li, Xiaoxiang Chen, Dahong Yao, Lu Yang, Hangyu Wang, Jian Huang, Jinhui Wang*. Novel steroid and sesquiterpenes isolated from Saussurea involucrata. Phytochemistry Letters, 2021, 41: 129-133.
[2] Cui Huanyue, Liu Xueying, Zhang Jin, Zhang Ke*, Yao Dahong, Dong Shi, Feng Shushu, Yang Lu, Li Yuyao, Wang Hangyu*, Huang Jian, Wang Jinhui*. Rhodiola rosea L. Attenuates Cigarette Smoke and Lipopolysaccharide-Induced COPD in Rats via Inflammation Inhibition and Antioxidant and Antifibrosis Pathways.
[3] Qingdong Ma, Xiaoxiang Chen, Ke Zhang*, Dahong Yao, Lu Yang, Hangyu Wang, Santai Bulemasi, Jian Huang, Jinhui Wang*. Chemical Fingerprint Analysis for Discovering Markers and Identifying Saussurea involucrate by HPLC Coupled with OPLS-DA. Journal of Analytical Methods in Chemistry, 2020, 2020:7560710-7560717.
[4] Aibibula Litipijiang, Xiaobo Pang, Yun Zhu, Jian Huang , Hangyu Wang, Le Gao, Xu Liang, Long Chen, Ke Zhang*, Jinhui Wang*. Analyses and identification of the chemical constituents of the Uighur formulation Baixuan Xiatare using three-stage infrared spectroscopy. Journal of Traditional Chinese Medicine, 2020, 40(5):875-882.
[5] Xiaobin Xin, Dahong Yao, Ke Zhang*, Shuai Han, Danni Liu, Hangyu Wang, Xueying Liu, Guoyu Li, Jian Huang, Jinhui Wang*. Protective effffects of Rosavin on bleomycin-induced pulmonary fifibrosis via suppressing fifibrotic and inflflammatory signaling pathways in mice. Biomedicine & Pharmacotherapy, 2019, 115:108870-108877.
[6] Shu-Yun Wang, Guo-Yu Li, Ke Zhang, Hang-Yu Wang, Hong-Gang Liang, Chao Huang, Jian Huang, Jin-Hui Wang*, Bao-Feng Yang. New ingol-type diterpenes from the latex of Euphorbia resinifera. Journal of Asian Natural Products Research, 2019, 21(11):1075-1082.
[7] Qu Tiange, Zhu Yun, Zhang Ke, Huang Jian, Wang Hangyu, Gao Le, Liang Xu, Chen Long, Wang Jinhui, Pang Xiaobo*, Duan Xingwu*. Commonalities and characteristics of aqueous extracts from three Uighur medicines were analyzed by using three-stage infrared spectroscopy combined with ultra- performance liquid chromatography- time of flight-mass spectra. Journal of traditional Chinese medicine, 2019, 39(1):118-126.
[8] Shuyun Wang, Yaping Guo, Dahong Yao, Lijun Liu, Henglei Duan, Lingwei Meng, Hong Yang, Ke Zhang*, Jian Huang*, Qin Li, Wei Xiao, Jinhui Wang, Baofeng Yang. 4-Alkyl-5,7-dihydroxycoumarins from the flflowering buds of Mesua ferrea. Fitoterapia, 2019, 138:104192-104198.
[9] Long Chen#, Dan-ni Liu#, Yu Wang, Xue-ying Liu, Shuai Han, Ke Zhang*, Guo-yu Li, Xing Tian*, Hang-yu Wang*, Jin-hui Wang. Treatment with MQA, a Derivative of Caffeoylquinic Acid, Provides Neuroprotective Effects against Cerebral Ischemia Through Suppression of the p38 Pathway and Oxidative Stress in Rats. Journal of Molecular Neuroscience, 2019, 67(4): 604-612.
[10] Xiaobo Pang, Ke Zhang, Jian Huang, Hangyu Wang, Le Gao, Tao Wang, Yingnan Sun, Long Chen, Jinhui Wang*. Decryption of Active Constituents and Action Mechanism of the Traditional Uighur Prescription (BXXTR) Alleviating IMQ-Induced Psoriasis-Like Skin Inflammation in BALB/c Mice. International Journal of Molecular Sciences, 2018, 19: 1822-1839
[11] Cai Zhang, Xing Tian*, Ke Zhang, Guo-Yu Li, Hang-Yu Wang, Jin-Hui Wang. Protective effects of Foeniculum vulgare root bark extract against carbon tetrachloride-induced hepatic fibrosis in mice. World Journal of Gastroenterology 2017, 23(31): 5722-5731
[12] Ke Zhang, Xiao-ping Si, Jian Huang*, Jian Han, Xu Liang, Xiaobo Xu, Guo-yu Li, Yi-ting Wang, Hang-yu Wang, Jin-hui Wang*. Preventive effects of Rhodiola rosea L. on bleomycin-induced pulmonary fibrosis in rats. International journal of Molecular Sciences. 2016, 17: 879-900
2. 发明专利
[1] 王金辉,热娜·卡斯木,李国玉,黄健,姚大红,胡君萍,马庆东,张珂,陈雪珊. 多刺绿绒蒿α-糖苷酶抑制活性提取物及其组合物的医药用途和制备方法[P]. 中国:CN201510058737.3, 2018-04-20
[2] 李国玉,张珂,李晓东,卢立娜,魏秀岩. 蔷薇红景天总苷及其医药用途和制备方法[P]. 中国:CN201010177549.X, 2012-01-18
六、联系方式
1. E-mail:tcm_zk@163.com
2. 通讯地址:新疆维吾尔自治区石河子市北二路59号,石河子大学医学校区,药学院
3. 邮编:832002