郑秋生 导师简介

发布者:教科办发布时间:2017-07-13浏览次数:316

 

1.基本信息

郑秋生,男,汉族,1967年10月生,山东寿光人,博士,教授,博士生导师。

2003年6月毕业于兰州大学细胞生物学专业学习,获理学博士学位;

2005-2008年在北京大学天然药物与仿生药物国家重点实验室博士后流动站工作。

2006年起在石河子大学药学院工作,现任新疆特种植物药资源教育部重点实验室主任。

2006年入选教育部新世纪优秀人才支持计划。

2.研究方向

  肿瘤与心脑血管药理学

3.开设课程

主要承担《高级药理学》、《专业英语》、《自由基生物学与医学》等本科生和研究生课程的理论和实验教学工作。

4.主持科研项目

主持国家重大科技专项1项,国家十一五支撑计划1项,973前期研究专1项,科技部中小企业发展计划1项,国家自然科学基金4项,省部级课题20余项。明细如下:

(1)新疆特种植物药物质基础与作用机制研究创新团队,新疆生产建设兵团(2015BD005),60万元,主持人郑秋生, 2015.01- 2018.01  

(2)异甘草素调控糖代谢诱导黑色素瘤细胞凋亡机制研究,,国家自然科学基金(项目编号31471338)90万元,主持人郑秋生,2015.01-2018.12

(3)甘草查尔酮A 诱导膀胱癌T24 细胞凋亡机制研究,国家自然科学基金(项目编号81260338)55万元,主持人郑秋生,2012-2016;

(4)光果甘草中三种化合物联合分离新技术研发及中试(13C26216516410),科技型中小企业创业投资引导基金,80万元,主持人郑秋生,2014.1-2016.12

(5)新疆独特生境下植物次生多酚类产物的抗肿瘤活性研究,兵团杰出青年基金(项目编号2011CD006),30万元,主持人郑秋生,2011-2013。

(6)异甘草素诱导HL-60细胞分化机制的研究,国际科技合作计划(2012BC001),13万元,主持人郑秋生,2012-2014;

(7)异甘草素诱导肿瘤细胞从分化到凋亡过程中氧化还原调控机制研究,973计划前期研究专项(2010CB535003),2009-2012主持人,70万元

(8)NADPH氧化酶在异甘草素诱导HL-60细胞分化中的作用研究,国家自然科学基金(项目编号30960451),主持人,22万,2010-2012

(9)化药一类抗肿瘤新药维泰醇及维泰醇类化合物成药性研究,科技部重大新药创制科技重大专项(2009ZX09103-141),428.61万元,主持人,2009-2012

(10)活性氧在阿片代谢过程中产生机制及其对阿片受体结合能力的影响国家自然科学基金(项目编号30860074),主持人,25万元2009-2011

(11)抗肝纤维化复方新药甘草紫参片的研究与开发国家“十一五”支撑计划主持人 2007-2009  (2006BAI06A18-22) 180万元

(12)新疆特色植物药资源的研究与开发教育部新世纪优秀人才支持计划主持人 2007-2009,50万元,NCET-06-0918

(13)自治区优秀创新群体项目“新疆特色植物药研究开发XJEDU2007G04郑秋生

5. 主要学术成果

曾主持或参与国家“863”、“973”、国家自然科学基金等重大研究项目三十余项,先后参与十多个新药开发项目的药效学评价研究工作,其中已申报并批准临床新药9项,待申报或批准临床达10多项,申请相关专利多项。在国内外学术期刊发表论文250余篇,其中SCI、EI收录论文105余篇,出版专著5部,参编国外英文专著2部,获得省部级科技进步一等奖2项,二等奖5项。现为多家国际学术期刊编委、约稿人或特邀审稿人。明细如下:

获奖情况

(1)2016年度兵团科学技术合作奖;新兵发〔2016〕58号, 新疆生产建设兵团, 2016年12月10日

精确放疗同步中药优化治疗高危肿瘤与临床防护技术的应用,2005年中国人民解放军医疗成果奖二等奖,第4位。中国人民解放军总后勤部

(2)系统药理学理论和氧还调控技术在筛选评价抗肿瘤药物上的应用,2014年兵团科技进步一等奖,第1位。

(3)中医证候物质基础与中药功效分子网络靶点生物系统学解析,2014年山东省自然科学二等奖,第1位。

(4)天山“乌头草”中毒的临床治疗技术研究与示范,2012年新疆生产建设兵团科学技术进步三等奖,第3位

(5)波狼毒灌注RF加温IMCRT治疗肿瘤与战时辐射损伤的相关研究. 2010年全军科技进步二等奖;第2位。

(6)抗癌新药异甘草素的临床实验研究,2009年新疆生产建设兵团科学技术进步二等奖,第1位。

(7)中药联合SFR并透热加温治疗肿瘤的临床防护研究,2005中华中医药学会科学技术一等奖 , 第2位。

(8)中药灌注RF加温IMCRT治疗肿瘤的防护研究,2009年山东省科学技术进步二等奖,第8位。

(9)3D立体放射X(γ)线治疗肿瘤辐射损伤的临床防护研究,2004全军医疗成果科技进步二等奖, 第3位。

(10)亚硒酸钠和维生素C诱导肿瘤细胞再分化的机制,2003山东省教育厅自然科学进步三等奖,第1位。

(11)对口支援西部高校工作十周年突出贡献个人,2011年,中华人民共和国教育部。

授权发明专利

(1)张波,王晓琴,郑秋生,黄方爱,杨晓燕. 一种升高葡萄白藜芦醇含量的方法[Z]. CN102047827A: ,2011. (第三专利人)

(2)张波,王晓琴,郑秋生,一种诱导葡萄氐类物质积累的方法,ZL201210380456.6,(第三专利人)

发表的论文

[1]  Lingling Si, Xinhui Yang, Xinyan Yan, Yanming Wang, Qiusheng Zheng. Isoliquiritigenin induces apoptosis of human bladder cancer T24 cells via the Cyclin-dependent kinases-independent mechanism. Oncology Letters. Published online on: May 12, 2017  

[2]  Wang J, Li Y, Yang Y, Chen X, Du J, Zheng Q, Liang Z, Wang Y.A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula.Sci Rep. 2017 May 4;7(1):1504. doi: 10.1038/s41598-017-01613-7.

[3]  Chen XY, Li DF, Han JC, Wang B, Dong ZP, Yu LN, Pan ZH, Qu CJ, Chen Y, Sun SG, Zheng QS.Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3β signaling.Oncotarget. 2017 Mar 29. doi: 10.18632/oncotarget.16655. [Epub ahead of print]

[4]  Caixia Gao, Xinyan Yan, Bo Wang, Lina Yu, Jichun Han, Defang Li, Qiusheng Zheng: Jolkinolide B induces apoptosis and inhibits tumor growth in mouse melanoma B16F10 cells by altering glycolysis. Scientific Reports 11/2016; 2016(6:36114 | DOI: 10.1038/srep36114)., DOI:10.1038/srep36114

[5]  Lina Yu, Jun Ma, Jichun Han, Bo Wang, Xiaoyu Chen, Caixia Gao, Defang Li, Qiusheng Zheng: Licochalcone B Arrests Cell Cycle Progression and Induces Apoptosis in Human Breast Cancer MCF-7 Cells. Recent Pat Anticancer Drug Discov. 09/2016; 11(4)., DOI:10.2174/1574892811666160906091405

[6]  Shi-Liang Jia, Xue-Ling Wu, Xiao-Xiao Li, Xue-Ling Dai, Zhao-Lan Gao, Zheng Lu, Qiu-Sheng Zheng, Ya-Xuan Sun: Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-β1-42 oligomers injected into the hippocampus. Journal of Asian natural products research 09/2016; 18(12)., DOI:10.1080/10286020.2016.1201811

[7]  Jichun Han, Defang Li, Xiaoyu Chen, Fanqing Meng, Bo Wang, Xinjie Zhang, Qiusheng Zheng: Effects of Licochalcone A on Cell-cycle Distribution and Glycolysis in Human Bladder Cancer T24 Cells. Journal of food and nutrition research 08/2016; 4(8)., DOI:10.12691/jfnr-4-8-9

[8]  Jichun Han, Defang Li, Xiaoyu Chen, Fanqing Meng, Bo Wang, Xinjie Zhang, Qiusheng Zheng: Hepatoprotective Activities of Huoshan Dendrobium Officinale Kimura et Migo Water Extracts on Carbontetrachloride-induced Hepatotoxicity in Mice.. DOI:10.12691/jfnr-4-8-10

[9]  Xiaoyu Chen, Ming Yang, Wenjin Hao, Jichun Han, Jun Ma, Caixia Wang, Shiguo Sun, Qiusheng Zheng: Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq. Gene 07/2016; 592(1)., DOI:10.1016/j.gene.2016.07.052

[10]  Caixia Wang, Wenjuan Xu, Wenjin Hao, Bingsheng Wang, Qiusheng Zheng: Alternol inhibits the proliferation and induces the differentiation of the mouse melanoma B16F0 cell line. Oncology Reports 06/2016; 36(2)., DOI:10.3892/or.2016.4844

[11]  Xinhui Yang, Jiangtao Jiang, Xinyan Yang, Jichun Han, Qiusheng Zheng: Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels. Molecular Medicine Reports 05/2016; 14(1)., DOI:10.3892/mmr.2016.5334

[12]  Yanming WANG, Jun MA, Xinyan YAN, Xiaoyu CHEN, Lingling SI, Ying LIU, Jichun HAN, Wenjin HAO, Qiusheng ZHENG: Isoliquiritigenin inhibits proliferation and induces apoptosis via alleviating hypoxia and reducing glycolysis in melanoma B16F10 cells. Recent Patents on Anti-Cancer Drug Discovery 03/2016; 11(999)., DOI:10.2174/1573406412666160307151904

[13]  Wenjuan Wang, Xiaotang Ma, Jichun Han, Mingjie Zhou, Huanhuan Ren, Qunwen Pan, Chunli Zheng, Qiusheng Zheng: Neuroprotective Effect of Scutellarin on Ischemic Cerebral Injury by Down-Regulating the Expression of Angiotensin-Converting Enzyme and AT1 Receptor. PLoS ONE 01/2016; 11(1)., DOI:10.1371/journal.pone.0146197

[14] Shiliang Jia, Zheng Lu, Zhaolan Gao, Jun An, Xueling Wu, Xiaoxiao Li, Xueling Dai, Qiusheng Zheng, Yaxuan Sun. Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-β1-42-induced rat model of Alzheimer's disease. Int J Biol Macromol. 2016 Feb;83:416-25. doi: 10.1016/j.ijbiomac.2015.11.011. Epub 2015 Nov 18.

[15] Yun Han, Jun Wu, Tingting Liu, Youdong Hu, Qiusheng Zheng, Binsheng Wang, Haiyan Lin, Xia Li. Separation, characterization and anticancer activities of a sulfated polysaccharide from Undaria pinnatifida.  Int J Biol Macromol. 2016 Feb;83:42-9. doi: 10.1016/j.ijbiomac.2015.11.049. Epub 2015 Nov 23.

[16]Daoxu Qu, Jichun Han, Huanhuan Ren, Wenxiao Yang, Xinjie hang, Qiusheng Zheng, Dong Wang. Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart. Oxidative medicine and cellular longevity, VOLUME 2016 (2016)(ARTICLE ID 8194690,):11 PAGES · DECEMBER 2015

[17]Penglong Wang, Xuan Yuan, Yan Wang, Hong Zhao, Xiling Sun, Qiusheng Zheng: Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells. Molecular Medicine Reports 09/2015; 12(5). DOI:10.3892/mmr.2015.4346

[18]Xuan Yuan, Hai-tao Niu, Peng-long Wang, Jie Lu, Hong Zhao, Shi-han Liu, Qiu-sheng Zheng, Chang-gui Li: Cardioprotective Effect of Licochalcone D against Myocardial Ischemia/Reperfusion Injury in Langendorff-Perfused Rat Hearts. PLoS ONE 06/2015; 10(6):e0128375. DOI:10.1371/journal.pone.0128375

[19] Wenjin Hao, Xuan Yuan, Lina Yu, Caixia Gao, Xiling Sun, Dong Wang, Qiusheng Zheng: Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. Scientific Reports 05/2015; 5:10336. DOI:10.1038/srep10336

[20]Mingjie Zhou, Liqun Liu, Wenjuan Wang, Jichun Han, Huanhuan Ren, Qiusheng Zheng, Dong Wang: Role of licochalcone C in cardioprotection against ischemia / reperfusion injury of isolated rat heart via antioxidant, anti-inflammatory, and anti-apoptotic activities. Life sciences 04/2015; 132. DOI:10.1016/j.lfs.2015.04.008

[21]Mingjie Zhou, Huanhuan Ren, Jichun Han, Wenjuan Wang, Qiusheng Zheng, Dong Wang: Protective Effects of Kaempferol against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3. Oxidative medicine and cellular longevity 03/2015; Article ID 481405(1):1-8. DOI:10.1155/2015/481405

[22]Xuejiao Hou, Jichun Han, Changsheng Yuan, Huanhuan Ren, Ya Zhang, Tao Zhang, Lixia Xu, Qiusheng Zheng, Wen Chen: Cardioprotective Effects of Total Flavonoids Extracted from Xinjiang Sprig Rosa rugosa against Acute Ischemia/Reperfusion-Induced Myocardial Injury in Isolated Rat Heart. Cardiovascular toxicology 01/2015;  DOI:10.1007/s12012-015-9308-0

[23]Ma jun, Yuan Xuan, Qu Hengyi, Zhang juan, Wang dong, Sun Xiling, Zheng Qiusheng: The role of reactive oxygen species in morphine addiction of SH-SY5Y cells. Life sciences 01/2015; 124. DOI:10.1016/j.lfs.2015.01.003

[24] Caixia Wang, B Zhang, N Chen, Liangliang Liu, Jinglei Liu, Q Wang, Zhenhua Wang, Xiling Sun, Qiusheng Zheng. Alteronol Induces Differentiation of Melanoma B16F0 Cells. Recent Pat Anticancer Drug Discov. 2014 Sep 23. . 2015;10(1):116-27.

[25] Jichun Han, Dong Wang,Bacui Yu, YanmingWang, Huanhuan Ren, Bo Zhang, YonghuaWang, Qiusheng Zheng, Cardioprotection against Ischemia/Reperfusion by Licochalcone B in Isolated Rat Hearts. Oxidative Medicine and Cellular Longevity. Volume 2014, Article ID 134862, 11 pages,http://dx.doi.org/10.1155/2014/134862

[26]Zhao H1, Yuan X, Jiang J, Wang P, Sun X, Wang D, Zheng Q. Antimetastatic Effects of Licochalcone B on Human Bladder Carcinoma T24 by Inhibition of Matrix Metalloproteinases-9 and NF-кB Activity. Basic Clin Pharmacol Toxicol. 2014 May 26. doi: 10.1111/bcpt.12273.

[27]Binsheng Wang, Du Xing, Dong Wang, Qiusheng Zheng, Jun Ma, Sun Xiling, and Hengyi Qu. Protective effects of Elaeagnus angustifolia leaf extract against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart. Journal of Chemistry. Volume 2014, Article ID 693573, 6 pages.

[28]Wang Z, Wang D, Liu L, Guo D, Yu B, Zhang B, Han B, Sun XL Zheng QS. Alteronol inhibits the invasion and metastasis of B16F10 and B16F1 melanoma cells in vitro and in vivo. Life Sci. 2014 Mar 7;98(1):31-8. doi: 10.1016/j.lfs.2013.12.213. Epub 2014 Jan 8

[29]14. Jiang JT, Yuan X, Wang T, Chen T, Zhao H,Yan XY, Wang ZP, Sun XL, Zheng QS*. Antioxidative and Cardio-protective Effects of Total Flavonoids Extracted from Dracocephalum moldavica L., Cardiovascular Toxicology,2014 Jan 7. 01/2014; DOI:10.1007/s12012-013-9221-3

[30] Yuan X, Li T, Xiao E, Zhao H, Li Y, Fu S, Gan L, Wang Z, Zheng Q*, Wang Z. Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis. Food Chem Toxicol. Food Chem Toxicol. 2014 Mar;65:242-51. doi: 10.1016/j.fct.2013.12.030. Epub 2013 Dec 31.

[31] Liu L, Zhang B, Yuan X, Wang P, Sun X, Zheng QS*. Alternol induces an S-phase arrest of melanoma B16F0 cells. Cell Biol Int. 2014 Mar;38(3):374-80. doi: 10.1002/cbin.10226. Epub 2014 Jan 10.

[32] Jiang JT, Yuan X, Zhao H, Yan XY, Sun XL, Zheng QS*. Licochalcone A inhibits proliferation of bladder cancer T24 cells by inducing reactive oxygen species production. Biomed Mater Eng. 2014;24(1):1019-25. doi: 10.3233/BME-130899.

[33]Ya-Xuan Sun, Ting Liu, Xue-Ling Dai, Qiu-Sheng Zheng, Bo-Di,Hui & Zhao-Feng Jiang. Treatment with lutein provides neuroprotection in mice subjected to transient cerebral ischemia. Journal of Asian Natural Products Research, 2014,Vol. 00, No. 0, 1–10

[34] Bo Han, Mingming Zhang, Ting Tang, Qiusheng Zheng,Keyu Wang, Le Li, and Wen Chen. The long–term fate and toxicity of PEG–modified single–walled carbon nanotube isoliquiritigenin delivery vehicles in rats. Journal of Nanomaterials Received 28 October 2013; Journal of Nanomaterials. Volume 2014 (2014), Article ID 257391, 8 pages,http://dx.doi.org/10.1155/2014/257391

[35]Yuan X, Li DF, Zhao H, Jiang JT, Wang PL, Ma XY, Sun XL, Zheng QS*. Licochalcone-A-Induced Human Bladder Cancer T24 Cells Apoptosis Triggered by Mitochondria Dysfunction and Endoplasmic Reticulum Stress. BioMed Research International. Volume 2013, Article ID 474272, 9 pages

[36]Yuan X, Yu BC, Wang YM, Jiang JT, Liu LL, Zhao H, Wang Q, Zheng QS*. Involvement of Endoplasmic Reticulum Stress in Isoliquiritigenin-Induced SKOV-3 Cell Apoptosis. Recent Pat Anticancer Drug Discov. 2013 May 1;8(2):191-9. PubMed PMID: 22963151.

[37]Zhao H, Yuan X, Li DF, Chen HM, Jiang JT, Wang ZP, Sun XL, Zheng QS*. Isoliquiritigen Enhances the Antitumour Activity and Decreases the Genotoxic Effect of Cyclophosphamide. Molecules,2013, 18, 8786-8798; doi:10.3390/molecules18088786

[38]Chen HM, Zhang B, Yuan X, Yao Y, Zhao H, Sun XL, Zheng QS*. Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. Cell Biol Int. 2013 Jul 24. doi: 10.1002/ cbin.10156.

[39] Yuan X, Zhang B, Gan L, Wang ZH, Yu BC, Liu LL, Zheng QS*, Wang ZP. Involvement of the Mitochondrion-dependent and the Endoplasmic Reticulum Stress-signaling Pathways in Isoliquiritigenin-induced Apoptosis of HeLa Cell. Biomed Environ Sci. 2013 Apr;26(4):268-76. doi: 10.3967/0895-3988.2013.04.005

[40]Yu BC, Wang T, Zhang B, Wang ZH, Zheng QS*. Protective Effects of Total Flavonoids from Dracocephalum moldavica L. on Myocardial Ischemia /Reperfusion Injury in the Isolate Rats Heart. J PURE APPL MICROBIO. April 2013. Vol. 7(Spl. Edn,53-57  

[41]Han B, Zhang MM, Zheng QS, Wang XC, Tang T, Chen W. Sodium Carboxyl Methyl Cellulose for Improvement of the Determination of Polyethylene Glycol Modified Carbon Nanotubes by Raman Spectroscopy. Analytical Letters, 2013 in on page 130624060632006. Other IDs: 10.1080/00032719.2013.800535

[42] Penglong Wang, Fang Ran, Jiangtao Jiang, Bo Zhang, Xiling Sun, Qiusheng Zheng, Skikon induced K562 cell apoptosis through oxidative stress. Medical Plant, 2013,4(10):5-8

[43]Chen XY, Zhang B, Yuan X, Yang F, Liu J, Zhao H, Liu LL, Wang YM, Wang ZH, Zheng QS*. Isoliquiritigenin-induced differentiation in mouse melanoma B16F0 cell line. Oxid Med Cell Longev. 2012;2012:534934. doi: 10.1155/2012/534934. Epub 2012 Dec 10. PubMed PMID: 23304254; PubMed Central PMCID: PMC3529869.

[44]Chen HM, Zhang B, Yao Y, Chen N, Chen XY, Tian H, Wang ZH, Zheng QS*. NADPH oxidase-derived reactive oxygen species are involved in the HL-60 cell monocytic differentiation induced by isoliquiritigenin. Molecules. 2012 Nov 12;17(11):13424-38. doi: 10.3390/molecules171113424. PubMed PMID: 23147401

[45] Zhang B, Chen N, Chen HM, Wang ZH, Zheng QS*. The critical role of redox homeostasis in shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathway. Oxid Med Cell Longev. 2012;2012:781516. doi:10.1155/2012/781516. Epub 2012 Oct 15. PubMed PMID: 23119122; PubMed Central PMCID: PMC3478756

[46] Li H, Li L, Zheng QS, Kuroda C, Wang Q. Phaeophytin analogues from Ligularia knorringiana. Molecules. 2012 May 7;17(5):5219-24. doi:10.3390/molecules17055219. PubMed PMID: 22565475. IF=2.428

[47]Sun C, Wang ZH, Zheng QS, Zhang H. Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells. Phytomedicine. 2012 Feb 15;19(3-4):355-63. Epub 2011 Oct 5. IF=3.268

[48]Wang D, Yuan X, Liu T, Liu L, Hu Y, Wang Z, Zheng QS*. Neuroprotective activity of lavender oil on transient focal cerebral ischemia in mice. Molecules. 2012 Aug 15;17(8):9803-17. doi: 10.3390/molecules17089803.

[49] Yuan X, Zhang B, Chen N, Chen XY, Liu LL, Zheng QS*, Wang ZP. Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells. J Asian Nat Prod Res. 2012;14(8):789-98. doi: 10.1080/10286020.2012.694873. Epub 2012 Jun 14

[50]Yao Y, Zhang B, Chen H, Chen N, Liu L, Yishan W, Li C, Zheng QS*.Alteronol inhibits proliferation in HeLa cells through inducing a G1-phase arrest. J Pharm Pharmacol. 2012 Jan;64(1):101-7. doi: 10.1111/j.2042-7158.2011.01375.x. Epub 2011 Nov 10.

[51]Han B, Chen W, Zheng QS, Wang X, Yan H, Li L, Aisa H. Determination of isoliquiritigenin and its distribution in mice by synchronous fluorescence spectrometry. Anal Sci. 2011;27(11):1115-9.

[52]Wang CX, Zheng QS*, Wang YS, Chen XY, Chen N. The Critical Role of Isoliquiritigenin and Glabridin in Anti-metastasis. Journal of Convergence Information Technology. 2011(6):306-315

[53]Chen N, Wang CX, Zheng QS*, Wang YS, Chen XY, A Critical Role of Redox State in Determining HL-60Cell Differentiation. Procedia Environmental Sciences. Volume 8, 2011, Pages 653–660

[54]Wang Z, Liu T, Gan L, Wang T, Yuan X, Zhang B, Chen H, Zheng QS*. Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity. Eur J Pharmacol. 2010 Sep 25;643(2-3):211-7. doi:10.1016/j.ejphar.2010.06.027. Epub 2010 Jun 30. PubMed PMID: 20599918.

[55]Han B, Zheng QS. Wang JY,Chen W,Tang H, Wang Q, Wang XC,Li J. Isoliquiritigenin extracted from licorice Glycyrrhiza uralensis by facile conversion technique. Chemistry of Natural Products, 2010.Vol. 46, No. 4,523-527

[56]Chen Peng, Cui Yurong, Li Defang, Zheng QS*. Hepatoprotective effects of phenolic acid from Salviachinensis Benth. On CCl4 induced acute liver injury in mice.  Medicinal Plant 2010,1(4):36-38,41

[57]Sun YX, Tang Y, Wu AL, Liu T, Dai XL, Zheng QS*, Wang ZB. Neuroprotective effect of liquiritin against focal cerebral ischemia/reperfusion in mice via its antioxidant and antiapoptosis properties. J Asian Nat Prod Res. 2010 Dec;12(12):1051-60.

[58]Li DF, Wang ZH, Chen HM, Wang J, Zheng QS*. Isoliquiritigenin induces monocytic differentiation of HL-60 cells. Free Radic Biol Med. 2009 Mar 15;46(6):731-6. doi: 10.1016/j.freeradbiomed.2008.11.011. Epub 2008 Dec 3. PubMed PMID: 19110051.

[59]Zhao Peng,Wang Jingying, Ma Heng,Xiao Yao,He Leilei,Tong Chao, Wang Zhenhua, Zheng Qiusheng, E. Kurt Dolence, Sreejayan Nair, Ren Jun, Li Ji. A newly synthetic chromium complex-Chromium (D-phenylalanine)(3) activates AMP-activated protein kinase and stimulates glucose transport. Biochemical Pharmacology. 2009; 77(6):1002-1010

[60]Ma C, Li G, Zhang J, Zheng QS, Fan X, Wang Z. An efficient combination of supercritical fluid extraction and high-speed counter-current chromatography to extract and purify homoisoflavonoids from Ophiopogon japonicus (Thunb.) Ker-Gawler. J Sep Sci. 2009 Jun;32(11):1949-56. doi: 10.1002/jssc.200800732

6. 社会兼职  

The Open Bioactive Compound Journal,编委

Annals of Urological Research,Editorial Board for Annals of Urological Research,编委

American Journal of Laboratory Medicine, Editorial Member.编委

 American Journal of Leukemia Research编委

the International Journal of Pharmaceutical Sciences and Developmental Research.编委

Journal of Chemistry( Guest Edit a Special Issue)主编

SRL Urology编委

Global Journal of Advanced Radiation Research ;联合主编

Jacobs Journal of Drug Metabolism and Toxicology(编委)

The Editorial Board of Chinese Journal of Biology  编委

International Journal of Pharmaceutical Sciences and Developmental Research编委

ACS(American Chemical Society)会员

世界中医药学会网络药理学专业委员会副会长;

山东省心功能研究会健康与养生专业委员会副主任委员;

医药领域国家科技重大专项“十二五”计划技术管理专家,

西北天然药物(中藏药)产业技术创新战略联盟专家技术委员会委员

7. 联系方式

联系电话:18615016380;(0535-6913186)

E-mail:zqsyt@sohu.com

通讯地址:山东省烟台市观海路346号滨州医学院

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